Since November 2009, the USAID Health Care Improvement Project (HCI) has supported 96 health facilities across Uganda to improve the quality of HIV care services by applying improvement methods that enable sites to rapidly test changes in care processes to achieve better outcomes and spread these changes among all sites through peer-to-peer learning. This short report describes how HCI is supporting the Ministry of Health to institutionalize the capacity to do continuous quality improvement in HIV coverage, retention and clinical outcomes.